发明授权
EP1451188B1 DERIVES DE 4-(OXADIAZOL-3-YL)-1,4-DIAZABICYCLO 3.2.2]-NONANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
有权
4-（恶二唑-3-基）-1,4-二氮杂双环[3.2.2] -NONANDERIVATE，其制备和治疗用途
- 专利标题： DERIVES DE 4-(OXADIAZOL-3-YL)-1,4-DIAZABICYCLO 3.2.2]-NONANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
- 专利标题（英）： 4-(oxadiazol-3-yl)-1,4-diazabicyclo 3.2.2]-nonane derivatives, preparation and therapeutic use thereof
- 专利标题（中）： 4-（恶二唑-3-基）-1,4-二氮杂双环[3.2.2] -NONANDERIVATE，其制备和治疗用途
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申请号： EP02796853.6申请日： 2002-11-21
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公开(公告)号： EP1451188B1公开(公告)日： 2005-03-09
- 发明人: GALLI, Frédéric , LECLERC, Odile , LOCHEAD, Alistair
- 申请人： Sanofi-Aventis
- 申请人地址： 174, Avenue de France 75013 Paris FR
- 专利权人： Sanofi-Aventis
- 当前专利权人： Sanofi-Aventis
- 当前专利权人地址： 174, Avenue de France 75013 Paris FR
- 代理机构： Ludwig, Jacques
- 优先权： FR0115153 20011123
- 国际公布： WO2003044019 20030530
- 主分类号： C07D471/08
- IPC分类号： C07D471/08 ; A61K31/55 ; A61P25/00
摘要：
The invention concerns a compound of general formula (I), wherein: R represents a phenyl group substituted by one or several halogen toms, by one or several C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, trifluoromethoxy, trifluoromethyl, cyano, hydroxy, or methylenedioxy groups, or a pyridinyl group, or a thienyl group. The invention also concerns compounds which are nicotinic receptor ligands, and which are useful for treating or preventing disorders related to nicotinic receptor dysfunction, in particular in the central nervous system.
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