发明公开
- 专利标题: BENZOTHIAZOLES
- 专利标题(中): 苯并噻唑
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申请号: EP02805304.9申请日: 2002-12-05
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公开(公告)号: EP1456202A1公开(公告)日: 2004-09-15
- 发明人: FLOHR, Alexander , JAKOB-ROETNE, Roland , NORCROSS, Roger, David , RIEMER, Claus
- 申请人: F. Hoffman-la Roche AG
- 申请人地址: 124 Grenzacherstrasse 4070 Basle CH
- 专利权人: F. Hoffman-la Roche AG
- 当前专利权人: F. Hoffman-la Roche AG
- 当前专利权人地址: 124 Grenzacherstrasse 4070 Basle CH
- 代理机构: Poppe, Regina
- 优先权: EP01129273 20011212
- 国际公布: WO2003053961 20030703
- 主分类号: C07D417/04
- IPC分类号: C07D417/04 ; A61K31/428 ; A61P25/00
摘要:
The present invention relates to compounds of the general formula (1), wherein R1 3,6-dihydro-2H-pyran-4-yl, 5,6-dihydro-4H-pyran-3-yl, t,6-dihydro-4H-pyran-2-yl, tetrahydropyran-2,3 or 4-yl, cyclohex-1-enyl, cyclohexyl or is 1,2,3,6-tetrahydro-pyridin-4yl or piperidin-4-yl, which are optionally substituted C(O)CH3in the 1-position of the N-atom; R2 is lower alkyl, piperidin-1yl, optionally substituted by hydroxy, or is phenyl, optionally substituted by (CH2)n-N(R')-C(O)-(CH2)n-NR'2,-(CH2)n-halogen, lower alkyl or (CH2)n-O-lower alkyl, or is morpholinyl or is pyridinyl, which is optionally substituted by halogen, -N(R')-(CH2)n-O-lower alkyl, lower alkyl, lower alkoxy, morpholinyl or (CH2)n-pyrrolidinyl; n is 0, 1 or 2; R' is hydrogen or lower alkyl, and to pharmaceutically acceptable acid addition salts thereof. It has been found that the compounds of general formula I are adenosine receptor ligands. Specifically, the compounds of the present invention have a good affinity to the A2A-receptor and they may be used in the treatment of diseases, related to this receptor.
公开/授权文献
- EP1456202B1 BENZOTHIAZOLES 公开/授权日:2005-11-09
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