发明公开
EP1461061A2 COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS
审中-公开
组合物和方法对于具有趋化因子受体相关的检测和治疗疾病和症状
- 专利标题： COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS
- 专利标题（中）： 组合物和方法对于具有趋化因子受体相关的检测和治疗疾病和症状
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申请号： EP02786859.5申请日： 2002-12-02
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公开(公告)号： EP1461061A2公开(公告)日： 2004-09-29
- 发明人: BURNS, Jennifer, M. , MIAO, Zhenhua , WEI, Zheng , HOWARD, Maureen, C. , PREMACK, Brett, A. , SCHALL, Thomas, J.
- 申请人： Chemocentryx, Inc.
- 申请人地址： 1539 Industrial Road San Carlos, CA 94070 US
- 专利权人： Chemocentryx, Inc.
- 当前专利权人： Chemocentryx, Inc.
- 当前专利权人地址： 1539 Industrial Road San Carlos, CA 94070 US
- 代理机构： Broughton, Jon Philip
- 优先权： US338100P 20011130; US337961P 20011130; US245850 20020916; EP02256808 20020930
- 国际公布： WO2003047420 20030612
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; G01N33/53 ; G01N33/537 ; C12N15/00 ; C12N5/00
摘要：
Compositions and Methods for Detecting and Treating Diseases and Conditions Related to Chemokine ReceptorsABSTRACT OF THE DISCLOSUREThe present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor.
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