发明公开
EP1468690A1 Use of estrogens for the treatment of infertility in male mammals
有权
Verwendung von Estrogenen zur Behandlung vonMännerunfruchtbarkeit
- 专利标题： Use of estrogens for the treatment of infertility in male mammals
- 专利标题（中）： Verwendung von Estrogenen zur Behandlung vonMännerunfruchtbarkeit
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申请号： EP03075894.0申请日： 2003-03-27
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公开(公告)号： EP1468690A1公开(公告)日： 2004-10-20
- 发明人: Maas, Jacob Jan , Coelingh Bennink, Herman Jan Tijmen , Nieschlag, Eberhard
- 申请人： Pantarhei Bioscience B.V.
- 申请人地址： Boslaan 13 3701 CH Zeist NL
- 专利权人： Pantarhei Bioscience B.V.
- 当前专利权人： Pantarhei Bioscience B.V.
- 当前专利权人地址： Boslaan 13 3701 CH Zeist NL
- 代理机构： Jorritsma, Ruurd
- 主分类号： A61K31/565
- IPC分类号： A61K31/565 ; A61K38/11 ; A61P15/08
摘要：
The present invention relates to a method of improving the fertility of a male mammal. More particularly, the present invention relates to a method of improving the fertility of a male mammal, said method comprising administering to said male mammal estrogen or a combination of estrogen and oxytocin agonist in an amount effective to increase the reproductive quality of the male's semen. Generally accepted parameters that are indicative of the reproductive quality of semen include total sperm count, sperm concentration, ejaculate volume, sperm motility and sperm morphology.
Another aspect of the invention relates to an intranasal drug delivery system comprising an intranasal drug delivery device and a drug delivery composition for intranasal delivery, said composition containing at least 3 µg/ml estrogen, at least 3 µg/ml oxytocin agonist and pharmaceutically acceptable excipient.
Another aspect of the invention relates to an intranasal drug delivery system comprising an intranasal drug delivery device and a drug delivery composition for intranasal delivery, said composition containing at least 3 µg/ml estrogen, at least 3 µg/ml oxytocin agonist and pharmaceutically acceptable excipient.
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