发明公开
EP1470107A2 FLUORO SUBSTITUTED CYCLOALKANOINDOLES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
有权
氟取代CYCLOALKANINDOLE及其作为前列腺素D2受体拮抗剂
- 专利标题： FLUORO SUBSTITUTED CYCLOALKANOINDOLES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
- 专利标题（中）： 氟取代CYCLOALKANINDOLE及其作为前列腺素D2受体拮抗剂
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申请号： EP03700740.8申请日： 2003-01-22
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公开(公告)号： EP1470107A2公开(公告)日： 2004-10-27
- 发明人: BERTHELETTE, Carl , LACHANCE, Nicolas , LI, Lianhai , STURINO, Claudio , WANG, Zhaoyin
- 申请人： MERCK FROSST CANADA & CO.
- 申请人地址： 16711 Trans Canada Highway Kirkland, Quebec H9H 3L1 CA
- 专利权人： MERCK FROSST CANADA & CO.
- 当前专利权人： MERCK FROSST CANADA & CO.
- 当前专利权人地址： 16711 Trans Canada Highway Kirkland, Quebec H9H 3L1 CA
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US351384P 20020124
- 国际公布： WO2003062200 20030731
- 主分类号： C07D209/80
- IPC分类号： C07D209/80 ; A61K31/403 ; A61P43/00 ; C07D209/88
摘要：
Fluoro substituted cycloalkanoindole derivatives of formula (I) and pharmaceutically acceptable salts thereof, wherein n is 0 or 1; m is 1, 2 or 3; R1 is H, C1-C3 alkyl, halogenated C1-C3 alkyl or cyclopropyl; R2 is 4-chlorophenyl or 2,4,6-trichlorophenyl are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases.
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