发明公开
EP1470220A2 SELECTIVE ENZYMATIC ESTERIFICATION AND SOLVOLYSIS OF EPIMERIC VITAMIN D ANALOG AND SEPARATION OF THE EPIMERS
有权
酶促选择性酯化和溶剂分解差向异构体维生素D类似物和差向异构体分离
- 专利标题： SELECTIVE ENZYMATIC ESTERIFICATION AND SOLVOLYSIS OF EPIMERIC VITAMIN D ANALOG AND SEPARATION OF THE EPIMERS
- 专利标题（中）： 酶促选择性酯化和溶剂分解差向异构体维生素D类似物和差向异构体分离
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申请号： EP03729607.6申请日： 2003-01-09
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公开(公告)号： EP1470220A2公开(公告)日： 2004-10-27
- 发明人: SHAPIRO, Evgeny , FISHMAN, Ayelet , EFFENBERGER, Reinhard , MAYMON, Asher , SCHWARTZ, Anchel
- 申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD.
- 申请人地址： 5 Basel Street,P.O. Box 3190 49131 Petah Tiqva IL
- 专利权人： TEVA PHARMACEUTICAL INDUSTRIES LTD.
- 当前专利权人： TEVA PHARMACEUTICAL INDUSTRIES LTD.
- 当前专利权人地址： 5 Basel Street,P.O. Box 3190 49131 Petah Tiqva IL
- 代理机构： Bradley, Josephine Mary
- 优先权： US348082P 20020110; US349977P 20020118
- 国际公布： WO2003060094 20030724
- 主分类号： C12N9/20
- IPC分类号： C12N9/20
摘要：
Provided is a method of selectively enzymatically esterifying or selectively enzymatically solvolyzing epimers of analogs of vitamin D having a stereogenic center at C-24 that has a free or esterified OH group. The method can be used, for example, for separating mixed epimers of the vitamin D analog.
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