发明公开
- 专利标题： GAMMA SECRETASE INHIBITORS
- 专利标题（中）： γ分泌酶抑制剂
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申请号： EP03737650.6申请日： 2003-02-05
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公开(公告)号： EP1472223A1公开(公告)日： 2004-11-03
- 发明人: PISSARNITSKI, Dmitri, A. , JOSIEN, Hubert, B. , SMITH, Elizabeth, M. , CLADER, John, W. , ASBEROM, Theodros , GUO, Tao , HOBBS, Douglas, W.
- 申请人： SCHERING CORPORATION , PHARMACOPEIA, INC.
- 申请人地址： 2000 Galloping Hill Road Kenilworth,New Jersey 07033-0530 US
- 专利权人： SCHERING CORPORATION,PHARMACOPEIA, INC.
- 当前专利权人： SCHERING CORPORATION,PHARMACOPEIA, INC.
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth,New Jersey 07033-0530 US
- 代理机构： Adams, Harvey Vaughan John
- 优先权： US355618P 20020206
- 国际公布： WO2003066592 20030814
- 主分类号： C07D211/96
- IPC分类号： C07D211/96 ; C07D401/12 ; A61K31/4427 ; A61P25/18
摘要：
This invention discloses novel gamma secretase inhibitors of the formula:(Chemical formula should be inserted here as it appears on abstract in paper form)wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 is an R1 group, alkyl, -X(CO)Y, or alkylene-X(CO)Y wherein X and Y are as defined herein; each R3 and each R3A are independently H, or alkyl; R11 is aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. Also disclosed is a method of treating Alzheimer s Disease using one or more compounds of the invention.
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