发明公开
- 专利标题： METHOD OF TREATING AND PREVENTING BONE LOSS
- 专利标题（中）： 方法用于治疗和预防骨质收缩的
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申请号： EP03704519.2申请日： 2003-02-03
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公开(公告)号： EP1476153A2公开(公告)日： 2004-11-17
- 发明人: ALLARD, John, David , KLEIN, Robert, Frederick , PELTZ, Gary, Allen
- 申请人： F. Hoffmann-La Roche AG , The Government of the United States , Oregon Health & Science University
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F. Hoffmann-La Roche AG,The Government of the United States,Oregon Health & Science University
- 当前专利权人： F. Hoffmann-La Roche AG,The Government of the United States,Oregon Health & Science University
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Witte, Hubert, Dr.
- 优先权： US355255P 20020208
- 国际公布： WO2003066048 20030814
- 主分类号： A61K31/407
- IPC分类号： A61K31/407 ; A61K31/404 ; A61K31/192 ; A61K31/167 ; A61P19/10 ; A61P19/08 ; A61P19/02
摘要：
Methods of treating and preventing bone loss and/or enhancing bone formation are disclosed. The methods utilize 15-lipoxygenase inhibitors. These molecules can be delivered alone or in combination with agents which inhibit bone resorption or additional agents that regulate calcium resorption from bone or enhances bone accumulation. The invention additionally provides methods of diagnosing a predisposition to bone loss.
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