发明公开
- 专利标题： METHODS OF INHIBITING ORTHOPOXVIRUS REPLICATION WITH NUCLEOSIDE COMPOUNDS
- 专利标题（中）： 与核苷化合物正痘的复制的抑制
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申请号： EP03707772.4申请日： 2003-02-07
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公开(公告)号： EP1476169A1公开(公告)日： 2004-11-17
- 发明人: OLSEN, David, B. , LAFEMINA, Robert, L. , ELDRUP, Anne, B. , BERA, Sanjib
- 申请人： Merck & Co., Inc. , ISIS PHARMACEUTICALS, INC.
- 申请人地址： 126 East Lincoln Avenue Rahway,New Jersey 07065-0907 US
- 专利权人： Merck & Co., Inc.,ISIS PHARMACEUTICALS, INC.
- 当前专利权人： Merck & Co., Inc.,ISIS PHARMACEUTICALS, INC.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway,New Jersey 07065-0907 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US356805P 20020213
- 国际公布： WO2003068244 20030821
- 主分类号： A61K31/7052
- IPC分类号： A61K31/7052 ; A61K31/7076 ; A61K31/708
摘要：
The present invention provides methods of inhibiting orthopoxvirus replication and/or treating orthopoxvirus infection with certain nucleoside compounds and derivatives thereof. These compounds are particularly useful as inhibitors of vaccinia virus and variola virus replication and/or for the treatment of vaccinia virus and variola virus infection. The nucleoside compounds may be administered alone or in combination with other agents active against orthopoxvirus infection, in particular against vaccinia virus or variola virus infection. Another aspect of the present invention provides for the use of such nucleoside compounds in the manufacture of a medicament for the inhibition of orthopoxvirus replication and/or for the treatment of orthopoxvirus infection. Yet a further aspect of the present invention provides such nucleoside compounds for use as a medicament for the inhibition of orthopoxvirus replication and/or for the treatment of orthopoxvirus infection.
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