发明公开
EP1479667A1 PROCESS FOR PRODUCING CHROMONE COMPOUND
审中-公开
VERFAHREN ZUR HERSTELLUNG EINER CHROMONVERBINDUNG
- 专利标题： PROCESS FOR PRODUCING CHROMONE COMPOUND
- 专利标题（中）： VERFAHREN ZUR HERSTELLUNG EINER CHROMONVERBINDUNG
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申请号： EP03707123.0申请日： 2003-02-27
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公开(公告)号： EP1479667A1公开(公告)日： 2004-11-24
- 发明人: HIBINO, Hiroaki , OHTSUKA, Susumu , MIYAMOTO, Yasunobu , YOSHIDA, Tomoyasu , OKUMOTO, Itsuo
- 申请人： Sumitomo Chemical Company, Limited , ONO PHARMACEUTICAL CO., LTD.
- 申请人地址： 5-33, Kitahama 4-chome, Chuo-ku Osaka-shi Osaka 541-8550 JP
- 专利权人： Sumitomo Chemical Company, Limited,ONO PHARMACEUTICAL CO., LTD.
- 当前专利权人： Sumitomo Chemical Company, Limited,ONO PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 5-33, Kitahama 4-chome, Chuo-ku Osaka-shi Osaka 541-8550 JP
- 代理机构： VOSSIUS & PARTNER
- 优先权： JP2002053315 20020228; JP2002053316 20020228; JP2002169675 20020611; JP2002169676 20020611
- 国际公布： WO2003080555 20031002
- 主分类号： C07C201/12
- IPC分类号： C07C201/12 ; C07C205/37 ; C07C67/307 ; C07C69/63 ; C07D311/24
摘要：
A process for producing a dicarboxylic acid compound represented by the formula (4):
wherein R 1 and R 2 are the same or different and each represents lower alkyl and the wavy line indicates that this compound is the E- or Z-isomer or a mixture of them, characterized by reacting a compound represented by the formula (2):
wherein R 1 , R 2 and the wavy line have the same meanings as the above, and one of X 2 and X 3 represents hydrogen and the other represents halogen, with nitrophenol represented by the formula (3):
in the presence of a base; a process for producing a nitrochromone compound represented by the formula (5):
wherein R 1 has the same meaning as the above, characterized by reacting the dicarboxylic acid compound or carboxylic acid thereof with an acid; a process for producing an aminochromone compound which comprises reducing the nitrochromone compound; and a process for producing an amidochromone compound which comprises acylating the aminochromone compound are provided.
wherein R 1 and R 2 are the same or different and each represents lower alkyl and the wavy line indicates that this compound is the E- or Z-isomer or a mixture of them, characterized by reacting a compound represented by the formula (2):
wherein R 1 , R 2 and the wavy line have the same meanings as the above, and one of X 2 and X 3 represents hydrogen and the other represents halogen, with nitrophenol represented by the formula (3):
in the presence of a base; a process for producing a nitrochromone compound represented by the formula (5):
wherein R 1 has the same meaning as the above, characterized by reacting the dicarboxylic acid compound or carboxylic acid thereof with an acid; a process for producing an aminochromone compound which comprises reducing the nitrochromone compound; and a process for producing an amidochromone compound which comprises acylating the aminochromone compound are provided.
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