发明授权
EP1482951B1 ALPHA-HYDROXY-2-METHYLENE-10-NOR-PREGNACALCIFEROL AND ITS USES
有权
1-ALPHA-羟基-2-甲基-19-非 - 普瑞米卡尔
- 专利标题： ALPHA-HYDROXY-2-METHYLENE-10-NOR-PREGNACALCIFEROL AND ITS USES
- 专利标题（中）： 1-ALPHA-羟基-2-甲基-19-非 - 普瑞米卡尔
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申请号： EP02795796.8申请日： 2002-12-10
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公开(公告)号： EP1482951B1公开(公告)日： 2006-10-04
- 发明人: DELUCA, Hector F. , PLUM, Lori, A. , CLAGETT-DAME, Margaret
- 申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
- 申请人地址： 614 Walnut Street Madison, WI 53705 US
- 专利权人： WISCONSIN ALUMNI RESEARCH FOUNDATION
- 当前专利权人： WISCONSIN ALUMNI RESEARCH FOUNDATION
- 当前专利权人地址： 614 Walnut Street Madison, WI 53705 US
- 代理机构： McCluskie, Gail Wilson
- 优先权： US77916 20020218
- 国际公布： WO2003075932 20030918
- 主分类号： A61K31/59
- IPC分类号： A61K31/59 ; C07C401/00 ; A61P17/00 ; A61P17/06 ; A61P35/00
摘要：
This invention discloses 1 alpha -a-hydroxy-2-methylene-19-nor-pregnacalciferol and pharamaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkels, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any calcemic activity and therefore may be used to treat immune disorders in humans as well as renal osteodystrophy.
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