The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising: a) an actuator (100) comprising: i) an outer body defining a top of the actuator, the outer body containing a cavity; ii) a controller board comprising driving electronics and a battery, the controller board being positioned within the cavity; and iii) an interface connection port for receiving a porator array, the interface connection port containing an anode and a cathode; b) a reservoir patach attached to the an extention tub, the reservoir patch being applied to the microporated area of a tissue membrane after poration.