发明公开
EP1483415A4 A NON-INVASIVE DIAGNOSTIC TEST UTILIZING HISTONE MODIFICATION MARKERS
审中-公开
无创诊断测试使用HISTONMODIFIZIERTER MARKER
- 专利标题： A NON-INVASIVE DIAGNOSTIC TEST UTILIZING HISTONE MODIFICATION MARKERS
- 专利标题（中）： 无创诊断测试使用HISTONMODIFIZIERTER MARKER
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申请号： EP03742781申请日： 2003-02-19
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公开(公告)号： EP1483415A4公开(公告)日： 2006-02-01
- 发明人: ALLIS C DAVID , BRUNS DAVID E , DRUMMOND ALAN H
- 申请人： UNIV VIRGINIA , CHROMA THERAPEUTICS LTD
- 专利权人： UNIV VIRGINIA,CHROMA THERAPEUTICS LTD
- 当前专利权人： UNIV VIRGINIA,CHROMA THERAPEUTICS LTD
- 优先权： US35832502 2002-02-20; US36545902 2002-03-19
- 主分类号： C07K1/22
- IPC分类号： C07K1/22 ; C07K16/18 ; C12M1/00 ; C12N15/09 ; C12P19/34 ; C12Q1/68 ; G01N33/53 ; G01N33/68 ; G01N37/00
摘要：
The present invention relates to the use of antibodies directed against specific histone amino terminus modifications as diagnostic indicators of disease or congenital defects. In one embodiment, nucleosomes are isolated from a blood or serum sample of a patient using histone specific antibodies and the accompanying DNA is purified and analyzed for diagnostic and screening purposes.
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