发明公开
- 专利标题： PROCESS FOR PREPARING CRYSTALLINE FORM I OF CABERGOLINE
- 专利标题（中）： 用于生产结晶形式，卡麦角林
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申请号： EP03712002.9申请日： 2003-03-10
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公开(公告)号： EP1485383A1公开(公告)日： 2004-12-15
- 发明人: SHEIKH, Ahmad, Y. , TOMASI, Attilio
- 申请人： Pharmacia Corporation , Pharmacia Italia S.p.A.
- 申请人地址： 100 Route 206 North Peapack, NJ 07977 US
- 专利权人： Pharmacia Corporation,Pharmacia Italia S.p.A.
- 当前专利权人： Pharmacia Corporation,Pharmacia Italia S.p.A.
- 当前专利权人地址： 100 Route 206 North Peapack, NJ 07977 US
- 代理机构： Wood, David John
- 优先权： US364567P 20020315; US410163P 20020912
- 国际公布： WO2003078433 20030925
- 主分类号： C07D457/06
- IPC分类号： C07D457/06
摘要：
A process for producing crystalline form I of cabergoline, which process comprises the preparation of Form V using heptane as precipitation solvent, and its exclusive conversion into crystalline Form I of cabergoline. The present crystallization process from toluene-heptane solvent system for form V involves 'reverse addition' of toluene-cabergoline concentrate to cold heptane.
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