发明公开
EP1492536A1 4- ( N-PHENYLAMINO ) -CHINAZOLINE/CHINOLINE ALS TYROSINKINASEINHIBITOREN
有权
4-(N-苯基氨基)-CHINAZOLINE /喹啉作为酪氨酸激酶抑制剂
- 专利标题: 4- ( N-PHENYLAMINO ) -CHINAZOLINE/CHINOLINE ALS TYROSINKINASEINHIBITOREN
- 专利标题(英): 4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors
- 专利标题(中): 4-(N-苯基氨基)-CHINAZOLINE /喹啉作为酪氨酸激酶抑制剂
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申请号: EP03745271.1申请日: 2003-03-25
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公开(公告)号: EP1492536A1公开(公告)日: 2005-01-05
- 发明人: HIMMELSBACH, Frank , JUNG, Birgit , SOLCA, Flavio
- 申请人: Boehringer Ingelheim Pharma GmbH & Co.KG
- 申请人地址: Binger Strasse 173 55216 Ingelheim am Rhein DE
- 专利权人: Boehringer Ingelheim Pharma GmbH & Co.KG
- 当前专利权人: Boehringer Ingelheim Pharma GmbH & Co.KG
- 当前专利权人地址: Binger Strasse 173 55216 Ingelheim am Rhein DE
- 优先权: DE10214412 20020330; DE10231711 20020713
- 国际公布: WO2003082290 20031009
- 主分类号: A61K31/517
- IPC分类号: A61K31/517 ; C07D239/94 ; C07D405/12 ; C07D401/12 ; C07D413/12 ; C07D403/12 ; C07D498/08 ; C07D491/08 ; A61P35/00
摘要:
The invention relates to the bicyclic heterocycles of the general formula (I), wherein Ra, Rb, Rc, Rd and X are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, especially the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, especially an inhibitory effect on tyrosine kinase-mediated signal transduction. The invention also relates to the use of the bicyclic heterocycles in the treatment of diseases, especially cancer diseases and of benign prostate hyperplasia (BPH), of diseases of the lung and the respiratory system, and further to the production of the bicyclic heterocycles.
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