发明公开
EP1494677A1 USE OF METHYLENE BLUE AND RELATED COMPOUNDS TO PREVENT OR REVERSE AN EXAGGERATED HEMODYNAMIC REACTION
审中-公开
使用亚甲蓝和防止或逆转夸张的血流动力学反应相关的化合物
- 专利标题: USE OF METHYLENE BLUE AND RELATED COMPOUNDS TO PREVENT OR REVERSE AN EXAGGERATED HEMODYNAMIC REACTION
- 专利标题(中): 使用亚甲蓝和防止或逆转夸张的血流动力学反应相关的化合物
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申请号: EP03745238.0申请日: 2003-03-28
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公开(公告)号: EP1494677A1公开(公告)日: 2005-01-12
- 发明人: JUNEAU, Martin , TANGUAY, Jean-François , BROUILLETTE, Denis
- 申请人: Institut de Cardiologie de Montreal
- 申请人地址: 5000 Bélanger Street East Montreal,Quebec H1T 1C8 CA
- 专利权人: Institut de Cardiologie de Montreal
- 当前专利权人: Institut de Cardiologie de Montreal
- 当前专利权人地址: 5000 Bélanger Street East Montreal,Quebec H1T 1C8 CA
- 代理机构: Schoppe, Fritz, Dipl.-Ing.
- 优先权: CA2379211 20020328
- 国际公布: WO2003082296 20031009
- 主分类号: A61K31/5415
- IPC分类号: A61K31/5415 ; A61P9/02 ; A61P39/02
摘要:
The present invention relates to the use of the dye methylene blue (MB) or a related compound to prevent or reverse an exaggerated hemodynamic reaction in animals in need thereof, including humans. More specifically, the present invention concerns the use of MB or a related compound to prevent or reverse hypotension, unstable angina, myocardial infarction or shock caused by the concomitant ingestion of a phosphodiesterase inhibitor, such as sildenafil citrate, and a NO-donor, such as L-arginine, or an organic nitrate, such as nitroglycerin.
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