发明公开
- 专利标题： INHIBITORS OF AKT ACTIVITY
- 专利标题（中）： AKT抑制剂的影响
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申请号： EP03719597.1申请日： 2003-04-04
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公开(公告)号： EP1496896A1公开(公告)日： 2005-01-19
- 发明人: BILODEAU, Mark, T. , DUGGAN, Mark, E. , HARTNETT, John, C. , LINDSLEY, Craig, W. , MANLEY, Peter, J. , WU, Zhicai , ZHAO, Zhijian
- 申请人： Merck & Co., Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway,New Jersey 07065-0907 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway,New Jersey 07065-0907 US
- 代理机构： Horgan, James Michael Frederic
- 优先权： US370847P 20020408; US417174P 20021009
- 国际公布： WO2003086394 20031023
- 主分类号： A61K31/4375
- IPC分类号： A61K31/4375 ; A61K31/4709 ; A61K31/4985 ; A61K31/52 ; C07D401/14 ; C07D403/10 ; C07D403/14 ; C07D417/14 ; C07D473/32
摘要：
The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
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