发明公开
- 专利标题: MEANS AND METHODS FOR THE PRODUCTION OF ADENOVIRUS VECTORS
- 专利标题(中): 手段与方法用于生产腺病毒载体
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申请号: EP03753568.9申请日: 2003-04-24
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公开(公告)号: EP1497438A1公开(公告)日: 2005-01-19
- 发明人: VOGELS, Ronald , BOUT, Abraham
- 申请人: Crucell Holland B.V.
- 申请人地址: Archimedesweg 4 2333 CN Leiden NL
- 专利权人: Crucell Holland B.V.
- 当前专利权人: Crucell Holland B.V.
- 当前专利权人地址: Archimedesweg 4 2333 CN Leiden NL
- 代理机构: Klein, Bart
- 优先权: PCT/NL02/00280 20020425
- 国际公布: WO2003104467 20031218
- 主分类号: C12N15/86
- IPC分类号: C12N15/86
摘要:
The invention relates to methods and means for the production of adenoviral vectors on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is present in the adenoviral vector and wherein the E4-orf6 gene product is compatible with one or more products of the E1 gene products provided by the complementing cell, such that the adenoviral vector can be efficiently produced by the complementing cell.
公开/授权文献
- EP1497438B1 MEANS AND METHODS FOR THE PRODUCTION OF ADENOVIRUS VECTORS 公开/授权日:2009-10-28
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