发明公开
EP1501796A1 3-SUBSTITUTED AMINO-1H-INDOLE-2-CARBOXYLIC ACID AND 3-SUBSTITUTED AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS
有权
3-（吡啶基 - 氨基）-1H-吲哚-2-羧酸化合物AS白细胞介素-4基因表达的抑制剂的
- 专利标题： 3-SUBSTITUTED AMINO-1H-INDOLE-2-CARBOXYLIC ACID AND 3-SUBSTITUTED AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS
- 专利标题（中）： 3-（吡啶基 - 氨基）-1H-吲哚-2-羧酸化合物AS白细胞介素-4基因表达的抑制剂的
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申请号： EP03721841.9申请日： 2003-04-23
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公开(公告)号： EP1501796A1公开(公告)日： 2005-02-02
- 发明人: MERRIMAN, Gregory, H. , WEINTRAUB, Philip, M. , SABOL, Jeffrey, S. , DHARANIPRAGADA, Ramalinga , HRIB, Nicholas, J. , JURCAK, John, G. , GROSS, Alexandre , WHITELEY, Brian , MUSICK, Kwon, Yon , KLEIN, Joseph, T.
- 申请人： Aventis Pharmaceuticals Inc.
- 申请人地址： 300 Somerset Corporate Boulevard Bridgewater, New Jersey 08807-2854 US
- 专利权人： Aventis Pharmaceuticals Inc.
- 当前专利权人： Aventis Pharmaceuticals Inc.
- 当前专利权人地址： 300 Somerset Corporate Boulevard Bridgewater, New Jersey 08807-2854 US
- 代理机构： Jacobi, Markus Alexander, Dr.
- 优先权： US375304P 20020423; GB0217920 20020802
- 国际公布： WO2003091215 20031106
- 主分类号： C07D209/42
- IPC分类号： C07D209/42 ; C07D401/12 ; C07D409/12 ; C07D401/14 ; C07D405/14 ; C07D417/14 ; C07D417/12 ; C07D403/12 ; A61K31/40 ; A61P11/06 ; A61P37/08 ; A61P31/04 ; A61P35/00
摘要：
This inventions discloses and claims 3-substituted amino-1H-indole-2-carboxylic acid and 3-substituted amino-benzothiophene-2-carboxylic acid derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. It has now been found that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interieukin-4(IL-4) message, IL-4 release or IL-4 production.
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