发明公开
EP1501797A1 3-SUBSTITUTED AMINO-1H-INDOLE-2-CARBOXYLIC ACID AND 3-SUBSTITUTED AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS
有权
3-（氨基SUBSTITUTIERTE）-1H-吲哚-2-羧酸酯和3-（SUBSTITUTIERTE氨基） - 苯并[b]噻吩-2-羧酸酯化合物作为抑制剂的白介素-4基因表达
- 专利标题： 3-SUBSTITUTED AMINO-1H-INDOLE-2-CARBOXYLIC ACID AND 3-SUBSTITUTED AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS
- 专利标题（中）： 3-（氨基SUBSTITUTIERTE）-1H-吲哚-2-羧酸酯和3-（SUBSTITUTIERTE氨基） - 苯并[b]噻吩-2-羧酸酯化合物作为抑制剂的白介素-4基因表达
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申请号： EP03733867.0申请日： 2003-04-23
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公开(公告)号： EP1501797A1公开(公告)日： 2005-02-02
- 发明人: ALKAN, Sefik, S. , DINERSTEIN, Robert, J. , SUBRAMANIAM, Arun , HRIB, Nicholas, J. , JURCAK, John, G.
- 申请人： Aventis Pharmaceuticals, Inc.
- 申请人地址： 300 Somerset Corporate Boulevard Bridgwater, New Jersey 08807-2854 US
- 专利权人： Aventis Pharmaceuticals, Inc.
- 当前专利权人： Aventis Pharmaceuticals, Inc.
- 当前专利权人地址： 300 Somerset Corporate Boulevard Bridgwater, New Jersey 08807-2854 US
- 代理机构： Jacobi, Markus Alexander, Dr.
- 优先权： US375304P 20020423; GB0217920 20020802
- 国际公布： WO2003091214 20031106
- 主分类号： C07D209/42
- IPC分类号： C07D209/42 ; C07D401/12 ; C07D403/12 ; C07D409/12 ; C07D401/14 ; C07D405/14 ; A61K31/40 ; A61P11/06 ; A61P37/08 ; A61P31/04
摘要：
This invention discloses and claims substituted 3-amino-2-carboxylic acid indole and benzo(b)thiophene derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. In preferred embodiments of this invention it is also disclosed and claimed that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.
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