发明授权
- 专利标题: (IMIDAZOL-1-YL-METHYL)-PYRIDAZINE AS NMDA RECEPTOR BLOCKER
- 专利标题(中): (咪唑-1-基 - 甲基)哒嗪如NMDA受体阻断剂
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申请号: EP03752750.4申请日: 2003-05-16
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公开(公告)号: EP1506190B1公开(公告)日: 2006-06-14
- 发明人: BUETTELMANN, Bernd , HEITZ NEIDHART, Marie-Paule , JAESCHKE, Georg , PINARD, Emmanuel
- 申请人: F. HOFFMANN-LA ROCHE AG
- 申请人地址: Grenzacherstrasse 124 4070 Basel CH
- 专利权人: F. HOFFMANN-LA ROCHE AG
- 当前专利权人: F. HOFFMANN-LA ROCHE AG
- 当前专利权人地址: Grenzacherstrasse 124 4070 Basel CH
- 代理机构: Brodbeck, Michel
- 优先权: EP02010217 20020516
- 国际公布: WO2003097637 20031127
- 主分类号: C07D403/06
- IPC分类号: C07D403/06 ; C07D409/14 ; A61K31/505
摘要:
The present invention relates to compounds of formula (I) wherein A is an unsubstituted cyclic group; and R is hydrogen or lower alkyl; and pharmaceutically acceptable acid addition salts thereof. It has been shown that the compounds of formulas IA and IB are good NMDA NR-2B receptor subtype specific blockers. Possible therapeutic indications for these compounds include acute forms of neurodegeneration caused, e.g., by stroke and brain trauma, and chronic forms of neurodegeneration such as Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS(amyotrophic lateral sclerosis) and neurodegeneration associated with bacterial or viral infections and, in addition, depression and chronic and acute pain.
公开/授权文献
- EP1506190A1 (IMIDAZOL-1-YL-METHYL)-PYRIDAZINE AS NMDA RECEPTOR BLOCKER 公开/授权日:2005-02-16
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