发明公开
- 专利标题： BIS-TRANSITION-METAL-CHELATE-PROBES
- 专利标题（中）： 过渡金属螯合物PROBE
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申请号： EP02807321.1申请日： 2002-11-12
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公开(公告)号： EP1506402A2公开(公告)日： 2005-02-16
- 发明人: EBRIGHT, Richard, H. , EBRIGHT, Yon, W.
- 申请人： Rutgers, The State University of New Jersey
- 申请人地址： ASB III,3 Rutgers Plaza New Brunswick, NJ 08901 US
- 专利权人： Rutgers, The State University of New Jersey
- 当前专利权人： Rutgers, The State University of New Jersey
- 当前专利权人地址： ASB III,3 Rutgers Plaza New Brunswick, NJ 08901 US
- 代理机构： Walcher, Armin, Dipl.-Ing. Dr.
- 优先权： US367775P 20020328; US410267P 20020913
- 国际公布： WO2003091689 20031106
- 主分类号： G01N33/532
- IPC分类号： G01N33/532 ; C07D209/14
摘要：
A probe for labeling a target material is provided including two transition-metal chelates and detectable group. The probe has the general structural formula (I) wherein: (a) Y and Y' are each a transition metal, (b) R1 and R1 are each independently CH(COO-), CH(COOH), or absent; (c)R2 and R2 are linkers each having a length of from about 3.0 to about 20 Å; and (d) X is a detectable group. The linkers may be linear or branched, may contain aromatic moeties, and may optionally be further substituted. Methods of use of the probe in detecting and analyzing target materials of interest also are provided.
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