发明公开
EP1507000A2 A thermostable ligase mediated DNA amplification system for the detection of genetic diseases
失效
Hitzestabile Ligase enthaltende DNS-Amplifizierungssystem zur Bestimmung von genetischen Krankeiten
- 专利标题： A thermostable ligase mediated DNA amplification system for the detection of genetic diseases
- 专利标题（中）： Hitzestabile Ligase enthaltende DNS-Amplifizierungssystem zur Bestimmung von genetischen Krankeiten
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申请号： EP04077667.6申请日： 1991-04-29
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公开(公告)号： EP1507000A2公开(公告)日： 2005-02-16
- 发明人: Barany, Francis , Zebala, John , Nickerson, Deborah A. , Kaiser, Robert J., Jr. , Hood, Leroy
- 申请人： Cornell Research Foundation Inc. , CALIFORNIA INSTITUTE OF TECHNOLOGY
- 申请人地址： 20 Thornwood Avenue Ithaca, NY 14850 US
- 专利权人： Cornell Research Foundation Inc.,CALIFORNIA INSTITUTE OF TECHNOLOGY
- 当前专利权人： Cornell Research Foundation Inc.,CALIFORNIA INSTITUTE OF TECHNOLOGY
- 当前专利权人地址： 20 Thornwood Avenue Ithaca, NY 14850 US
- 代理机构： Jones, Stephen Anthony
- 优先权： US518447 19900503
- 主分类号： C12N9/00
- IPC分类号： C12N9/00 ; C12Q1/68 ; C12N15/00
摘要：
The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
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