发明授权
- 专利标题: NEW AGENTS FOR MAGNETIC IMAGING METHOD
- 专利标题(中): 剂磁成像方法
-
申请号: EP03735518.7申请日: 2003-06-02
-
公开(公告)号: EP1509254B1公开(公告)日: 2009-01-14
- 发明人: AIME, S.; c/o Bracco Imaging S.p.A. , MAINERO, V.; c/o Bracco Imaging S.p.A. , GENINATTI, Chrich S.; c/o Bracco Imaging S.p.A. , CABELLA, C.; c/o Bracco Imaging S.p.A.
- 申请人: BRACCO IMAGING S.p.A.
- 申请人地址: Via E. Folli, 50 20134 Milano IT
- 专利权人: BRACCO IMAGING S.p.A.
- 当前专利权人: BRACCO IMAGING S.p.A.
- 当前专利权人地址: Via E. Folli, 50 20134 Milano IT
- 代理机构: Poletti, Marco
- 优先权: EP02012531 20020605
- 国际公布: WO2003103722 20031218
- 主分类号: A61K49/08
- IPC分类号: A61K49/08 ; A61K41/00
摘要:
The invention provides MRI detectable species of formula (I): Dp-Sn-Nm, wherein D is a MRI detectable moiety; S is a spacer; N is a molecule of a nutrient or pseudo-nutrient; n is 0 or an integer; m is an integer and p is an integer. These compounds are useful for internalising into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalised in normal healthy cells thus allowing the diagnosis of tumors. The internalisation of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.
公开/授权文献
- EP1509254A1 NEW AGENTS FOR MAGNETIC IMAGING METHOD 公开/授权日:2005-03-02
信息查询