发明公开
EP1511760A2 CARBOXY PROTECTION STRATEGIES FOR ACIDIC C-TERMINAL AMINO ACIDS IN CHEMICAL LIGATION OF OLIGOPEPTIDES
有权
用于酸CARBOXYGRUPPENSCHUTZ C末端氨基酸，化工法整合寡肽
- 专利标题： CARBOXY PROTECTION STRATEGIES FOR ACIDIC C-TERMINAL AMINO ACIDS IN CHEMICAL LIGATION OF OLIGOPEPTIDES
- 专利标题（中）： 用于酸CARBOXYGRUPPENSCHUTZ C末端氨基酸，化工法整合寡肽
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申请号： EP03764091.9申请日： 2003-06-09
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公开(公告)号： EP1511760A2公开(公告)日： 2005-03-09
- 发明人: BOTTI, Paolo , VILLAIN, Matteo , MANGANIELLO, Sonia , GAERTNER, Hubert
- 申请人： Geneprot, Inc.
- 申请人地址： 2, rue Pré de la Fontaine,Case Postale 125 1217 Meyrin 2 CH
- 专利权人： Geneprot, Inc.
- 当前专利权人： Geneprot, Inc.
- 当前专利权人地址： 2, rue Pré de la Fontaine,Case Postale 125 1217 Meyrin 2 CH
- 代理机构： Thomson, Paul Anthony
- 优先权： US387825P 20020610
- 国际公布： WO2004007661 20040122
- 主分类号： C07K1/02
- IPC分类号： C07K1/02 ; C07K1/04 ; C07K1/06
摘要：
The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the presence of an unprotecte acidic C-terminal oligopeptide thioester. An important aspect of the present invention is providing side chain protected acidic C-terminal oligopeptide thioesters. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where aspartyl or glutamyl peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.
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