发明公开
EP1512403A1 Methods for making sustained-release pharmaceutical compositions of ergot alkaloids having improved bioavailability and compositions thereof
审中-公开
药物组合物和制造药物组合物的方法ergotalkaloidhaltigen缓释和改善的生物利用率
- 专利标题： Methods for making sustained-release pharmaceutical compositions of ergot alkaloids having improved bioavailability and compositions thereof
- 专利标题（中）： 药物组合物和制造药物组合物的方法ergotalkaloidhaltigen缓释和改善的生物利用率
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申请号： EP04105405.7申请日： 2000-11-30
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公开(公告)号： EP1512403A1公开(公告)日： 2005-03-09
- 发明人: Mailland, Federico
- 申请人： Polichem S.A.
- 申请人地址： 50 Val Fleuri 1526 Luxembourg LU
- 专利权人： Polichem S.A.
- 当前专利权人： Polichem S.A.
- 当前专利权人地址： 50 Val Fleuri 1526 Luxembourg LU
- 代理机构： Pistolesi, Roberto
- 优先权： US454364 19991203
- 主分类号： A61K31/48
- IPC分类号： A61K31/48 ; A61K9/20
摘要：
A method of improving bioavailability of ergot derivatives administered using sustained-release delivery systems includes combining an ergot derivative or mixture thereof with a pharmaceutically acceptable hydrophilic swelling agent or mixture thereof and one or more pharmaceutically acceptable excipients. The bioavailability of sustained-release formulations of the present invention is at least equal to the bioavailability of the ergot derivative or mixture thereof administered using a conventional delivery system. Sustained-release compositions that improve bioavailability are also provided. Methods and compositions according to the present invention may provide sustained-release characteristics while improving the bioavailability of ergot derivatives.
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