发明公开
EP1514547A1 CONTROLLED-RELEASE DRUG COMPOSITION
审中-公开
ARZNEIMITTELZUSAMMENSETZUNG MIT KONTROLLERERTER FREISETZUNG
- 专利标题： CONTROLLED-RELEASE DRUG COMPOSITION
- 专利标题（中）： ARZNEIMITTELZUSAMMENSETZUNG MIT KONTROLLERERTER FREISETZUNG
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申请号： EP03733434.9申请日： 2003-06-16
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公开(公告)号： EP1514547A1公开(公告)日： 2005-03-16
- 发明人: TANIZAWA, Yoshio , SHIMOKAWA, Tatsuharu , OGAWA, Hirotada , WATANABE, Mayumi , KOZAKI, Chihiro , KAWASHIMA, Hiroyuki , SHINODA, Yasuo , INAGI, Toshio
- 申请人： Kowa Co., Ltd. , Nissan Chemical Industries, Ltd.
- 申请人地址： 6-29, Nishiki 3-chome Naka-ku, Nagoya-shi, Aichi 460-8625 JP
- 专利权人： Kowa Co., Ltd.,Nissan Chemical Industries, Ltd.
- 当前专利权人： Kowa Co., Ltd.,Nissan Chemical Industries, Ltd.
- 当前专利权人地址： 6-29, Nishiki 3-chome Naka-ku, Nagoya-shi, Aichi 460-8625 JP
- 代理机构： Hartz, Nikolai, Dr.
- 优先权： US388740P 20020617
- 国际公布： WO2003105848 20031224
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61P3/06 ; A61P43/00
摘要：
The present invention is drawn to a pharmaceutical composition characterized by containing a composition (A) which contains pitavastatin, a salt thereof, or an ester thereof and which initiates release thereof at least in the stomach, and an enteric composition (B) which contains pitavastatin, a salt thereof, or an ester thereof. By use of the controlled release pharmaceutical compositlon of the present invention, the blood level of pitavastatin can be maintained at an appropriate level immediately after administration over a long period of time. Thus, highly safety and effective treatment of hypercholesterolemia can be performed.
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