发明公开
EP1523555A2 TRANSGENIC ANIMAL MODELS OF HRV WITH HUMANI ICAM-1 SEQUENCES
审中-公开
含有人ICAM-1序列的HRV的转基因动物模型
- 专利标题： TRANSGENIC ANIMAL MODELS OF HRV WITH HUMANI ICAM-1 SEQUENCES
- 专利标题（中）： 含有人ICAM-1序列的HRV的转基因动物模型
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申请号： EP03765071.0申请日： 2003-07-17
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公开(公告)号： EP1523555A2公开(公告)日： 2005-04-20
- 发明人: BLAIR, Edward DuncanC/O GlaxoSmithKline , CLARKE, Neil JamesGlaxoSmithKline , JOHNSTON, Sebastian LennoxNat. Heart And Lung In. , ROWLANDS, David JohnDiv. of Microbiology
- 申请人： GLAXO GROUP LIMITED
- 申请人地址： Glaxo Wellcome HouseBerkeley Avenue Greenford, Middlesex UB6 ONN GB
- 专利权人： GLAXO GROUP LIMITED
- 当前专利权人： GLAXO GROUP LIMITED
- 当前专利权人地址： Glaxo Wellcome HouseBerkeley Avenue Greenford, Middlesex UB6 ONN GB
- 代理机构： Priestley, Ruth Elizabeth
- 优先权： GB0216729 20020718
- 国际公布： WO2004009810 20040129
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; A01K67/027 ; C07K14/705 ; C12N15/62 ; C12N5/10 ; G01N33/50
摘要：
A transgenic non-human animal whose genome comprises a polynucleotide encoding human ICAM-1 domains D1 and D2 and preferably encoding human ICAM-1 domains D1 and D2 and host non-human ICAM-1 domains D3, D4 and D5. Methods for the production of such transgenic animals, screening methods using such transgenic animals, associated transgenes, constructs, vectors, and cells are disclosed. The transgenic non-human animal is a suitable model for studying human rhinovirus infection.
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