发明公开
EP1528923A1 N-((3-OXO-2,3-DIHYDRO-1H-ISOINDOL-1-YL)ACETYL)GUANIDINE DERIVATIVES AS NHE1-INHIBITORS FOR THE TREATMENT OF INFARCTION AND ANGINA PECTORIS
有权
N - （（3-氧代-2,3-二氢-1H-异吲哚-1-基）乙酰基）胍衍生物作为NHE1抑制剂用于治疗心绞痛的梗塞的治疗和
- 专利标题： N-((3-OXO-2,3-DIHYDRO-1H-ISOINDOL-1-YL)ACETYL)GUANIDINE DERIVATIVES AS NHE1-INHIBITORS FOR THE TREATMENT OF INFARCTION AND ANGINA PECTORIS
- 专利标题（中）： N - （（3-氧代-2,3-二氢-1H-异吲哚-1-基）乙酰基）胍衍生物作为NHE1抑制剂用于治疗心绞痛的梗塞的治疗和
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申请号： EP03730076.1申请日： 2003-05-20
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公开(公告)号： EP1528923A1公开(公告)日： 2005-05-11
- 发明人: KLEEMANN, Heinz-Werner , HOFMEISTER, Armin , CARRY, Jean-Christophe , MIGNANI, Serge , BIGOT, AntonyCentre de recherche de Paris , RONAN, Baptiste
- 申请人： Aventis Pharma Deutschland GmbH
- 申请人地址： Brüningstrasse 50 65929 Frankfurt am Main DE
- 专利权人： Aventis Pharma Deutschland GmbH
- 当前专利权人： Aventis Pharma Deutschland GmbH
- 当前专利权人地址： Brüningstrasse 50 65929 Frankfurt am Main DE
- 优先权： FR0206783 20020603
- 国际公布： WO2003101450 20031211
- 主分类号： A61K31/4035
- IPC分类号： A61K31/4035 ; A61K31/155 ; C07D209/46 ; C07C279/20 ; C07C277/08
摘要：
Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them. The present invention relates to the novel isoindolone derivatives of the Formula (I), in which R1 to R6 have the meanings stated in the claims. The inventive compounds are suitable as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.
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