发明授权
EP1530461B1 TRANSDERMALE VERABREICHUNG VON (R)-3,3-DIPHENYLPROPYLAMIN-MONOESTERN
有权
作者经皮给药（R）-3,3-二苯基丙胺单酯
- 专利标题： TRANSDERMALE VERABREICHUNG VON (R)-3,3-DIPHENYLPROPYLAMIN-MONOESTERN
- 专利标题（英）： Transdermal administration of (r)-3,3-diphenylpropylamine monoesters
- 专利标题（中）： 作者经皮给药（R）-3,3-二苯基丙胺单酯
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申请号： EP04725614.4申请日： 2004-04-03
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公开(公告)号： EP1530461B1公开(公告)日： 2007-10-03
- 发明人: BREITENBACH, Armin , MEESE, Claus , WOLFF, Hans-Michael , DREWS, Roland
- 申请人： SCHWARZ PHARMA AG
- 申请人地址： Alfred-Nobel-Strasse 10 40789 Monheim DE
- 专利权人： SCHWARZ PHARMA AG
- 当前专利权人： SCHWARZ PHARMA AG
- 当前专利权人地址： Alfred-Nobel-Strasse 10 40789 Monheim DE
- 优先权： DE10315878 20030408
- 国际公布： WO2004089346 20041021
- 主分类号： A61K9/70
- IPC分类号： A61K9/70 ; A61K31/403 ; C07C219/26
摘要：
The invention relates to a device for transdermally administering a compound of formula (I), wherein A represents hydrogen or deuterium, R represents a group selected among C1-6 alkyl, C3-10 cycloalkyl, or phenyl, each of which can be substituted by C1-3 alkoxy, fluoride, chlorine, bromine, iodine, nitro, amino, hydroxy, oxo, mercapto, or deuterium, the C atom marked by * (asterisk) being provided in the R configuration. The invention is characterized in that the compound of general formula (I) is provided in a polymer matrix and is released at a dose of 0.5 to 20 mg per day through human skin. The invention further relates to the use of said compounds of formula (I) for producing transdermal medicaments.
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