发明公开
- 专利标题： METHODS FOR PREPARING PURIFIED PROSTAGLANDIN E SYNTHASE
- 专利标题（中）： 制备纯化的前列腺素E合成酶的方法
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申请号： EP02757337.7申请日： 2002-08-23
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公开(公告)号： EP1532242A2公开(公告)日： 2005-05-25
- 发明人: JAKOBSSON, Per-Johan , WEINANDER, Rolf , MORGENSTERN, Ralf , LAMBALOT, Ralph, H.
- 申请人： Pfizer Products Inc. , Karolinska Innovations AB
- 申请人地址： 558, Eastern Point Road Groton,Connecticut 06340-5196 US
- 专利权人： Pfizer Products Inc.,Karolinska Innovations AB
- 当前专利权人： Pfizer Products Inc.,Karolinska Innovations AB
- 当前专利权人地址： 558, Eastern Point Road Groton,Connecticut 06340-5196 US
- 代理机构： Lee, Nicholas John
- 优先权： US314853P 20010824; US315405P 20010828
- 国际公布： WO2003018756 20030306
- 主分类号： C12N9/90
- IPC分类号： C12N9/90
摘要：
The invention provides purified preparations of prostaglandin E synthase (PGES), analogs and variants thereof, such as portions thereof, and fusion polypeptides comprising these. The invention also provides methods for obtaining these purified preparations; methods for identifying modulators of PGES, e.g., small molecules inhibiting or stimulating the activity of PGES; and methods for preparing prostaglandins. Nucleic acids encoding PGES polypeptides of the invention are also provided.
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