发明公开
- 专利标题： ARYL AND HETEROARYL MORPHOLINE DERIVATIVES
- 专利标题（中）： 芳基和杂吗啉
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申请号： EP03748975.4申请日： 2003-08-18
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公开(公告)号： EP1534694A1公开(公告)日： 2005-06-01
- 发明人: CASES-THOMAS, Manuel, Javier , HAUGHTON, Helen, Louise , LAMAS-PETEIRA, Carlos , OUWERKERK-MAHADEVAN, Sivi , MASTERS, John, Joseph , SIMMONDS, Robin, George , RUDYK, Hélène, Catherine, Eugénie , WALTER, Magnus, Wilhelm
- 申请人： ELI LILLY AND COMPANY
- 申请人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 当前专利权人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 代理机构： Kingsbury, Oliver William
- 优先权： GB0219687 20020823; US415305P 20021001
- 国际公布： WO2004018441 20040304
- 主分类号： C07D265/30
- IPC分类号： C07D265/30 ; C07D413/10 ; A61K31/5375 ; A61P25/00
摘要：
Compounds of formula (I) are selective inhibitors of the reuptake of norepinephrine, wherein Rx is H; Ry is H or C1-C4 alkyl; each Rz is independently H or C1-C4 alkyl; X represents O; Y represents OH or OR; R is C1-C4 alkyl; and Ar1 and Ar2 are optionally substituted phenyl or 5- or 6-membered heteroaryl rings.
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