发明公开
- 专利标题： MODIFIED GLP-1 PEPTIDES WITH INCREASED BIOLOGICAL POTENCY
- 专利标题（中）： 改进的GLP-1增加的生物有效性肽
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申请号： EP03753161.3申请日： 2003-09-25
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公开(公告)号： EP1543030A2公开(公告)日： 2005-06-22
- 发明人: GRAVEL, Denis , PERI, Krishna , ABRIBAT, Thierry , HABI, Abdelkrim
- 申请人： THERATECHNOLOGIES INC.
- 申请人地址： 2310 boulevard Alfred Nobel Saint-Laurent,Québec H4S 2A4 CA
- 专利权人： THERATECHNOLOGIES INC.
- 当前专利权人： THERATECHNOLOGIES INC.
- 当前专利权人地址： 2310 boulevard Alfred Nobel Saint-Laurent,Québec H4S 2A4 CA
- 代理机构： Desaix, Anne
- 优先权： US413171P 20020925
- 国际公布： WO2004029081 20040408
- 主分类号： C07K14/605
- IPC分类号： C07K14/605
摘要：
The present invention relates to a GLP-1 peptide having the following formula, or a pharmaceutically acceptable salt thereof: X-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-IIe-Ala-Trp-Leu-val-Lys-Gly-Arg-Y (SEQ ID NO.1), wherein X is a rigidifying hydrophobic moiety and wherein Y is selected from the group consisting of OH, NH2 and Gly-OH. Moreover, the present invention relates to pharmaceutical compositions comprising a therapeutically effective amount of a peptide of the present invention, or a pharmaceutically acceptable salt thereof, in association with at least one constituent selected from a pharmaceutically acceptable carrier, diluent, and excipient.
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