发明公开
- 专利标题： ANTI-ADDL ANTIBODIES AND USES THEREOF
- 专利标题（中）： 抗ADDL抗体及其用途
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申请号： EP03757505.7申请日： 2003-06-11
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公开(公告)号： EP1551447A2公开(公告)日： 2005-07-13
- 发明人: KLEIN, William, L. , KRAFFT, Grant, A. , LAMBERT, Mary, P. , VIOLA, Kirsten, L. , CHROMY, Brett, A. , GONG, Yue, Song , CHANG, Lei , MORGAN, Todd, E. , ROZOFSKY, Irina , FINCH, Caleb, E.
- 申请人： NORTHWESTERN UNIVERSITY , UNIVERSITY OF SOUTHERN CALIFORNIA
- 申请人地址： 633 Clark Street EvanstonIllinois 60208 US
- 专利权人： NORTHWESTERN UNIVERSITY,UNIVERSITY OF SOUTHERN CALIFORNIA
- 当前专利权人： NORTHWESTERN UNIVERSITY,UNIVERSITY OF SOUTHERN CALIFORNIA
- 当前专利权人地址： 633 Clark Street EvanstonIllinois 60208 US
- 代理机构： Richardson, Kate
- 优先权： US166856 20020611
- 国际公布： WO2003104437 20031218
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395 ; C07K16/00
摘要：
The invention herein comprises antibodies that bind to amyloid beta-derived diffusible ligands (ADDLs). ADDLs comprise amyloid ß protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.
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