ABSTRACTA packaged medical device produced according to the steps of positioning an antimicrobial agent source within a package comprising an inner surface, positioning a medical device within the package; and subjecting the package,the antimicrobial agent source and the medical device to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device, thereby substantially inhibiting bacterial colonization on the medical device.