发明公开
EP1562628A1 DC-SIGN BLOCKERS AND THEIR USE FOR PREVENTING OR TREATING VIRAL INFECTIONS.
有权
DC-SIGN受体阻滞剂和它们用于病毒感染的预防和治疗
- 专利标题： DC-SIGN BLOCKERS AND THEIR USE FOR PREVENTING OR TREATING VIRAL INFECTIONS.
- 专利标题（中）： DC-SIGN受体阻滞剂和它们用于病毒感染的预防和治疗
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申请号： EP03810566.4申请日： 2003-11-05
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公开(公告)号： EP1562628A1公开(公告)日： 2005-08-17
- 发明人: AMARA, Ali , ARENZANA-SEISDEDOS, Fernando , DESPRES, Philippe , VIRELIZIER, Jean-Louis
- 申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ETDE LA RECHERCHE MEDICALE (INSERM)
- 申请人地址： 25-28, rue du Docteur Roux 75724 Paris Cédex 15 FR
- 专利权人： INSTITUT PASTEUR,INSTITUT NATIONAL DE LA SANTE ETDE LA RECHERCHE MEDICALE (INSERM)
- 当前专利权人： INSTITUT PASTEUR,INSTITUT NATIONAL DE LA SANTE ETDE LA RECHERCHE MEDICALE (INSERM)
- 当前专利权人地址： 25-28, rue du Docteur Roux 75724 Paris Cédex 15 FR
- 代理机构： Vialle-Presles, Marie José
- 优先权： US423582P 20021105; US425246P 20021112
- 国际公布： WO2004041299 20040521
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61K39/42 ; A61K31/736 ; C12Q1/18 ; A61P31/14 ; A61P31/18
摘要：
The present invention relates to methods and compositions for preventing or treating diseases of a mammal, including viral infections, wherein at least one symptom of the disease is mediated at least in part by the binding of an effector molecule to a DC-SIGN receptor present on cells of the mammal to be treated. The invention also provides methods of identifying compositions, wherein the compositions are useful for treating mammalian diseases, including viral infections, for which at least one symptom of the disease is mediated at least in part by the specific binding of an effector molecule to a DC-SIGN receptor present on the cells that express the DC-SIGN receptor, belonging to the mammal to be treated. The invention further relates to compositions and methods for targeting subject molecules to cells that express the DC-SIGN receptor.
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