发明公开
EP1565193A2 METHODS AND COMPOSITIONS FOR TREATING CANCER USING PROTEASOME INHIBITORS
有权
组合物用于使用所述蛋白酶体抑制剂PS-341治疗癌症
- 专利标题： METHODS AND COMPOSITIONS FOR TREATING CANCER USING PROTEASOME INHIBITORS
- 专利标题（中）： 组合物用于使用所述蛋白酶体抑制剂PS-341治疗癌症
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申请号： EP03768749.8申请日： 2003-11-06
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公开(公告)号： EP1565193A2公开(公告)日： 2005-08-24
- 发明人: ANDERSON, Kenneth, C. , HIDESHIMA, Teru , MITSIADES, Constantine, S. , MITSIADES, Nicholas
- 申请人： DANA-FARBER CANCER INSTITUTE, INC.
- 申请人地址： 44 Binney Street Boston, MA 02115 US
- 专利权人： DANA-FARBER CANCER INSTITUTE, INC.
- 当前专利权人： DANA-FARBER CANCER INSTITUTE, INC.
- 当前专利权人地址： 44 Binney Street Boston, MA 02115 US
- 代理机构： Helbig, Christian
- 优先权： US424363P 20021106
- 国际公布： WO2004043374 20040527
- 主分类号： A61K31/69
- IPC分类号： A61K31/69
摘要：
The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.
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