发明公开
EP1567495A2 SMALL TECHNETIUM-99M AND RHENIUM LABELED AGENTS AND METHODS FOR IMAGING TISSUES, ORGANS AND TUMORS
审中-公开
很小，锝-99m和铼标记的试剂和图片编织机构和肿瘤的方法
- 专利标题： SMALL TECHNETIUM-99M AND RHENIUM LABELED AGENTS AND METHODS FOR IMAGING TISSUES, ORGANS AND TUMORS
- 专利标题（中）： 很小，锝-99m和铼标记的试剂和图片编织机构和肿瘤的方法
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申请号： EP03783254.0申请日： 2003-11-08
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公开(公告)号： EP1567495A2公开(公告)日： 2005-08-31
- 发明人: MAHMOOD, Ashfaq , CHENG, Zheng , JONES, Alun, G. , DAVISON, Alan
- 申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 申请人地址： 17 Quincy Street Cambridge, MA 02138 US
- 专利权人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE,MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE,MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人地址： 17 Quincy Street Cambridge, MA 02138 US
- 代理机构： Adam, Holger
- 优先权： US424980P 20021108
- 国际公布： WO2004043380 20040527
- 主分类号： C07D211/56
- IPC分类号： C07D211/56 ; C07D211/54 ; C07D211/52 ; C07D211/32 ; C07D211/18 ; C07C211/13 ; A01N33/02 ; A01N33/24 ; A01N37/18 ; A01N43/40
摘要：
The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors. In another embodiment, the invention relates the methods of imaging tissues, organs or tumors using radiolabeled metal complexes, particularly tissues, organs, or tumors which express certain receptors to which the compounds or complexes of the invention have an affinity. The present invention also relates to methods of treating cancer, particularly those cancer lines which express certain receptors to which the compounds or complexes of the invention have an affinity. In yet another embodiment, the present invention provides methods of imaging and/or inhibiting receptors or neuroreceptors using compounds or complexes of the invention which have an affinity for the receptor or neuroreceptor to be imaged and/or inhibited.
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