发明公开
EP1571158A2 Globular assembly of amyloid beta protein and uses thereof
无效
Globularer Aufbau vom淀粉样蛋白β-蛋白和deren Verwendungen
- 专利标题： Globular assembly of amyloid beta protein and uses thereof
- 专利标题（中）： Globularer Aufbau vom淀粉样蛋白β-蛋白和deren Verwendungen
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申请号： EP04027742.8申请日： 2000-08-04
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公开(公告)号： EP1571158A2公开(公告)日： 2005-09-07
- 发明人: Kraft, Grant A. , Klein, William L. , Chromy, Brett A. , Lambert, Mary P. , Finch, Caleb E. , Morgan, Todd , Wals, Pat , Rozovsky, Irina , Barlow, Ann
- 申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA , Northwestern University
- 申请人地址： University Park Los Angeles, California 90089 US
- 专利权人： THE UNIVERSITY OF SOUTHERN CALIFORNIA,Northwestern University
- 当前专利权人： THE UNIVERSITY OF SOUTHERN CALIFORNIA,Northwestern University
- 当前专利权人地址： University Park Los Angeles, California 90089 US
- 代理机构： Brown, John D.
- 优先权： US369236 19990804
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; A61K38/04 ; G01N33/68
摘要：
The invention provides amyloid beta-derived dementing ligands (ADDLs) that comprise amyloid β protein assembly bled into globular non-fibrillar oligomeric structures capable of activating specific cellular processes. The invention provides methods for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDLs, and modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.
公开/授权文献
- EP1571158B1 Globular assembly of amyloid beta protein and uses thereof 公开/授权日：2009-10-14
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