发明公开
- 专利标题： N-(INDOLETHYL-)CYCLOAMIN-VERBINDUNGEN
- 专利标题（英）： N-(indolethyl-)cacloamine compounds
- 专利标题（中）： N-（INDOLETHYL-）CYCLOAMIN-VERBINDUNGEN
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申请号： EP03795848.5申请日： 2003-11-27
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公开(公告)号： EP1572646A1公开(公告)日： 2005-09-14
- 发明人: HEINRICH, Timo , BÖTTCHER, Henning , SCHIEMANN, Kai , HÖLZEMANN, Günter , VAN AMSTERDAM, Christoph , BARTOSZYK, Gerd , LEIBROCK, Joachim , SEYFRIED, Christoph
- 申请人： Merck Patent GmbH
- 申请人地址： Frankfurter Strasse 250 64293 Darmstadt DE
- 专利权人： Merck Patent GmbH
- 当前专利权人： Merck Patent GmbH
- 当前专利权人地址： Frankfurter Strasse 250 64293 Darmstadt DE
- 优先权： DE10259244 20021217
- 国际公布： WO2004054972 20040701
- 主分类号： C07D209/14
- IPC分类号： C07D209/14 ; A61K31/404 ; A61P43/00 ; C07D209/42 ; C07D405/12 ; C07D417/12 ; A61K31/495
摘要：
The invention relates to n-(indolethyl-)cacloamine compounds of a formula (i), wherein R1, R1 x, Ar and n have a meaning of the claim 1. The inventive compounds consist of inhibitors of serotonin recapture (SSRI) and activators of serotoninenergic receptors 5-HT1A and 5-HT2A. Said compounds are used for preventing and treating various diseases of the central nervous system such as depression, dyskenesia, Parkinson's disease, dementia, vascular cerebral accident, schizophrenia, Alzheimer disease, Lewy bodies dementia, Huntington disease, Gille de la Tourette syndrome, anxiety, learning difficulties, memory disorder, pain, insomnia and neurodegenerative diseases.
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