发明授权
EP1581477B1 CYCLOALKENE DICARBOXYLIC ACID COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS 有权
环烯烃二羧酸化合物作为抗炎,免疫调节和抗增殖MEDIUM

  • 专利标题: CYCLOALKENE DICARBOXYLIC ACID COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS
  • 专利标题(中): 环烯烃二羧酸化合物作为抗炎,免疫调节和抗增殖MEDIUM
  • 申请号: EP03799487.8
    申请日: 2003-12-17
  • 公开(公告)号: EP1581477B1
    公开(公告)日: 2009-12-02
  • 发明人: LEBAN, JohannKRALIK, Martin
  • 申请人: 4SC AG
  • 申请人地址: Am Klopferspitz 19 a 82152 Martinsried DE
  • 专利权人: 4SC AG
  • 当前专利权人: 4SC AG
  • 当前专利权人地址: Am Klopferspitz 19 a 82152 Martinsried DE
  • 代理机构: Kilger, Ute
  • 优先权: DE10260800 20021223
  • 国际公布: WO2004056746 20040708
  • 主分类号: C07C233/57
  • IPC分类号: C07C233/57 A61P35/00 A61P37/02 A61P29/00 A61P31/12 A61K31/194
CYCLOALKENE DICARBOXYLIC ACID COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS
摘要:
The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein A is a non-aromatic ring system containing 4 to 8 carbon atoms, wherein the ring system comprises at least one double bond and wherein one or more of the carbon atoms in the ring can be replaced by a group X, wherein X is selected from the group consisting of S, O, N, NR4, SO, CO or SO2; D is O, S, SO2, NR4 or CH2; Z1 and Z2 are independent from each other O, S, or NR5 ; R2 is H, OR6, or NHR7; E is an alkyl or cycloalkyl group or a monocyclic or polycyclic substituted or unsubstituted ring system which may contain one or more groups X and which contains at least one aromatic ring; Y is hydrogen, halogen, haloalkyl, haloalkyloxy, alkyl, cycloalkyl, a monocyclic or polycyclic substituted or unsubstituted ring system for the use as a medicament.
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