发明授权
- 专利标题： PROMOTER VARIANTS FOR EXPRESSING GENES IN A FUNGAL CELL
- 专利标题（中）： 启动子选项表达的基因在真菌细胞
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申请号： EP03789880.6申请日： 2003-11-18
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公开(公告)号： EP1585822B1公开(公告)日： 2012-01-25
- 发明人: YAVER, Debbie , NHAM, Peter
- 申请人： Novozymes, Inc.
- 申请人地址： 1445 Drew Avenue Davis, CA 95616 US
- 专利权人： Novozymes, Inc.
- 当前专利权人： Novozymes, Inc.
- 当前专利权人地址： 1445 Drew Avenue Davis, CA 95616 US
- 代理机构： Rasmussen, Preben
- 优先权： US427314P 20021118
- 国际公布： WO2004046373 20040603
- 主分类号： C12P1/00
- IPC分类号： C12P1/00
摘要：
The present invention relates to methods for producing a biological substance, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the biological substance, wherein the fungal host cell comprises a first nucleic acid sequence encoding the biological substance operably linked to a second nucleic acid sequence comprising a promoter variant selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, and SEQ ID NO: 12; and a subsequence thereof; and hybrid and tandem promoters thereof; and (b) isolating the biological substance from the cultivation medium. The present invention also relates to the isolated promoter variants and to constructs, vectors, and fungal host cells comprising the promoter variants operably linked to nucleic acid sequences encoding biological substances.
公开/授权文献
- EP1585822A2 PROMOTER VARIANTS FOR EXPRESSING GENES IN A FUNGAL CELL 公开/授权日：2005-10-19
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