A pipetting device comprises a housing (1) with a handle (2) and a pipette (4) holder assembly (3), wherein the housing (1) end portion (7) incorporates a spherical raceway (16) to which the pipette (4) holding assembly (3) in mounted by the means of a connecting assembly (17) capable of sliding on the spherical raceway (16) at the housing (1) end portion (7) to facilitate the change of orientation angle of the pipette (4) axle in every plane with respect to the handle (2). The connecting assembly (17) comprises a first slider (18) slidably set in a rectangular opening (19) in the spherical raceway (16) at the housing (1) end portion (7), and a second slider (20) slidably set in a rectangular opening (21) in the first slider (18).