发明公开
- 专利标题： TRANSPOSON-BASED TARGETING SYSTEM
- 专利标题（中）： 基于TRANSPOSON的瞄准系统
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申请号： EP04709603.7申请日： 2004-02-10
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公开(公告)号： EP1594972A2公开(公告)日： 2005-11-16
- 发明人: IVICS, Zoltán , IZSVAK, Zsuzsanna
- 申请人： Max-Delbrück-Centrum für Molekulare Medizin (MDC)
- 申请人地址： Berlin-Buch, Robert-Rössle-Strasse 10 13125 Berlin DE
- 专利权人： Max-Delbrück-Centrum für Molekulare Medizin (MDC)
- 当前专利权人： Max-Delbrück-Centrum für Molekulare Medizin (MDC)
- 当前专利权人地址： Berlin-Buch, Robert-Rössle-Strasse 10 13125 Berlin DE
- 代理机构： Vossius & Partner
- 优先权： EP03002637 20030210
- 国际公布： WO2004069994 20040819
- 主分类号： C12N15/90
- IPC分类号： C12N15/90 ; C12N15/09
摘要：
The present invention relates to a targeting system comprising, preferably as distinct components, (a) a transposon which is devoid of a polynucleotide encoding a functional transposase comprising a polynucleotide of interest; and (b) a fusion protein comprising (ba) a transposase or a fragment or derivative thereof having transposase function; and (bb) a DNA targeting domain; or (bc) a (poly)peptide binding domain that binds to a cellular or engineered (poly)peptide comprising a DNA targeting domain; or (bd) a (poly)peptide comprising the DNA targeting domain of (bb) or the (poly)peptide binding domain of (bc), wherein the transposase or a fragment or derivative thereof having transposase function of (a) is joined by a linker to the domain of (bb) or to the domain of (bc) or to the (poly)peptide of (bd); or (c) a polynucleotide encoding the fusion protein of (b).
公开/授权文献
- EP1594972B1 TRANSPOSON-BASED TARGETING SYSTEM 公开/授权日：2011-02-09
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