发明公开
EP1599609A2 METHODS AND COMPOSITIONS FOR DETECTION AND ANALYSIS OF POLYNUCLEOTIDE-BINDING PROTEIN INTERACTIONS USING LIGHT HARVESTING MULTICHROMOPHORES
有权
用于检测方法和组合物及其POLYNUKLEOTIDBINDUNGSPROTEINWECHSELWIRKUNGEN的分析，使用聚光SANTANDER multichromophores
- 专利标题： METHODS AND COMPOSITIONS FOR DETECTION AND ANALYSIS OF POLYNUCLEOTIDE-BINDING PROTEIN INTERACTIONS USING LIGHT HARVESTING MULTICHROMOPHORES
- 专利标题（中）： 用于检测方法和组合物及其POLYNUKLEOTIDBINDUNGSPROTEINWECHSELWIRKUNGEN的分析，使用聚光SANTANDER multichromophores
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申请号： EP04737272.7申请日： 2004-02-13
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公开(公告)号： EP1599609A2公开(公告)日： 2005-11-30
- 发明人: BAZAN, Guillermo , LIU, Bin , WANG, Shu
- 申请人： The Regents of the University of California
- 申请人地址： 1111 Franklin Street Oakland, CA 94607-5200 US
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： 1111 Franklin Street Oakland, CA 94607-5200 US
- 代理机构： Reinhard - Skuhra - Weise & Partner
- 优先权： US447860P 20030213
- 国际公布： WO2004077014 20040910
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PBP that can bind to the target polynucleotide. The sensor PBP comprises a signaling chromophore to absorb energy from the excited multichromophore and emit light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
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