Method and device for freeze drying solutions and liquid containing solid substances, in which a vessel (1) is applied having a downwardly conical shape with inside a rotating mixing member (3) that moves with a small inter-space along the wall (2) of the vessel. With the new method in an advantageous manner free flowing products are obtained. Even new homogenous mixtures of a molecular scale of two or more substances are obtained, which are excellently usable in the industry of new materials.