发明公开
EP1603451A2 AMYLOID PLAQUE AS A TARGET FOR THERAPEUTICS THAT FUNCTION BY BLOCKING OR DISRUPTING CHITIN SYNTHESIS OR ACTIVITY
审中-公开
AMYLOID PLAQUE作为阻断或破坏甲状腺素合成或活性的治疗药物的目标
- 专利标题： AMYLOID PLAQUE AS A TARGET FOR THERAPEUTICS THAT FUNCTION BY BLOCKING OR DISRUPTING CHITIN SYNTHESIS OR ACTIVITY
- 专利标题（中）： AMYLOID PLAQUE作为阻断或破坏甲状腺素合成或活性的治疗药物的目标
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申请号： EP04718561.6申请日： 2004-03-08
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公开(公告)号： EP1603451A2公开(公告)日： 2005-12-14
- 发明人: HOLLINGSWORTH, Rawle, I. , ZIPSER, Birgit , HUANG, Linjuan
- 申请人： Michigan State University
- 申请人地址： 238 Administration Building East Lansing,Michigan 48824 US
- 专利权人： Michigan State University
- 当前专利权人： Michigan State University
- 当前专利权人地址： 238 Administration Building East Lansing,Michigan 48824 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： US453432P 20030310
- 国际公布： WO2004080285 20040923
- 主分类号： A61B1/00
- IPC分类号： A61B1/00
摘要：
Chitin has been discovered to accumulate in the diseased tissue of mammals, including humans, afflicted with a disease characterized by formation of congo red-staining plaques. Such diseases include Alzheimer's disease, spongiform encepalopathies, type II diabetes, atrial amyloidosis, and the like. A method for detecting the chitin in the mammal is described which is useful for diagnosing disease caused by accumulation of the chitin or amyloid plaques comprising chitin in tissue. Further described is a method for treating a disease in the mammal caused by the accumulation of chitin or amyloid plaques comprising chitin by administering a composition which inhibits formation of the chitin or degrades the chitin.
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