发明公开
- 专利标题： CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS
- 专利标题（中）： CXCR4趋化因子受体结合的化合物
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申请号： EP04759481申请日： 2004-04-12
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公开(公告)号： EP1613613A4公开(公告)日： 2009-03-25
- 发明人: BRIDGER GARY J , MCEACHERN ERNEST J , SKERLJ RENATO , SCHOLS DOMINIQUE , BAIRD IAN , KALLER AL , HARWIG CURTIS , ZHU YONGBAO , CHEN GANG , SKUPINSKA KRYSTYNA
- 申请人： ANORMED INC
- 专利权人： ANORMED INC
- 当前专利权人： ANORMED INC
- 优先权： US46273603 2003-04-11; US50568803 2003-09-23
- 主分类号： C07D401/02
- IPC分类号： C07D401/02 ; A61K31/44 ; A61K31/47 ; C07D213/38 ; C07D213/61 ; C07D213/65 ; C07D213/69 ; C07D213/70 ; C07D213/73 ; C07D213/74 ; C07D213/75 ; C07D213/76 ; C07D213/80 ; C07D213/82 ; C07D213/89 ; C07D401/12 ; C07D401/14 ; C07D409/14 ; C07D413/14 ; C07D417/12 ; C07D417/14 ; C07D451/04 ; C07D471/06
摘要：
The present invention relates to compounds that bind to chemokine receptors, and having the formula wherein each A, X, Y, R 1 , R 2 and R 3 are substituents. The present invention also relates to methods of using such compounds, such as in treating HIV infection and inflammatory conditions such as rheumatoid arthritis. Furthermore, the present invention relates to methods to elevate progenitor and stem cell counts, as well as methods to elevate white blood cell counts, using such compounds.
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