发明公开
EP1619194A3 Triazaspiro¬5.5|undecane derivatives and pharmaceutical composition comprising the same as active ingredient
审中-公开
Triazaspiro¬5.5| undecanderivative和含有它们作为活性成分的药物组合物
- 专利标题： Triazaspiro¬5.5|undecane derivatives and pharmaceutical composition comprising the same as active ingredient
- 专利标题（中）： Triazaspiro¬5.5| undecanderivative和含有它们作为活性成分的药物组合物
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申请号： EP05105154.8申请日： 2002-03-18
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公开(公告)号： EP1619194A3公开(公告)日： 2006-06-07
- 发明人: Habashita, Hiromu , Hamano, Shin-ichi , Shibayama, Shiro , Takaoka, Yoshikazu
- 申请人： ONO PHARMACEUTICAL CO., LTD.
- 申请人地址： 1-5, Doshomachi 2-chome, Chuo-ku Osaka-shi, Osaka 541-8526 JP
- 专利权人： ONO PHARMACEUTICAL CO., LTD.
- 当前专利权人： ONO PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 1-5, Doshomachi 2-chome, Chuo-ku Osaka-shi, Osaka 541-8526 JP
- 代理机构： Henkel, Feiler & Hänzel
- 优先权： JP2001079610 20010319; JP2001160251 20010529
- 主分类号： C07D471/10
- IPC分类号： C07D471/10 ; A61K31/503 ; A61K31/5377 ; A61P43/00 ; A61P29/00 ; A61P37/08 ; A61P11/06 ; A61P17/00 ; A61P17/04 ; A61P13/12 ; A61P1/16
摘要：
Triazaspiro[5.5]undecane derivatives of the formula (I), quaternary ammonium salts thereof, N-oxides thereof, non-toxic salts thereof, or pharmaceutical compositions comprising them, as active ingredients (wherein R 1 is formula (II) or formula (III); R 2 is alkyl or alkynyl etc.; R 3 , R 4 is H, (substituted) alkyl etc., or R 3 and R 4 together to form formula (IV); R 5 is H or alkyl).
Therefore the compounds of the formula (I) regulate the effect of chemokine/chemokine receptor, they are used for prevention and treatment of various inflammatory diseases, asthma, atopic dermatitis, urticaria, allergic diseases, nephritis, nephropathy, hepatitis, arthritis or rheumatoid arthritis etc.
Therefore the compounds of the formula (I) regulate the effect of chemokine/chemokine receptor, they are used for prevention and treatment of various inflammatory diseases, asthma, atopic dermatitis, urticaria, allergic diseases, nephritis, nephropathy, hepatitis, arthritis or rheumatoid arthritis etc.
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