Invention Publication
- Patent Title: OPTICAL FRACTIONATION METHODS AND APPARATUS
- Patent Title (中): 光学设备和分馏
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Application No.: EP04752357.6Application Date: 2004-05-14
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Publication No.: EP1625777A2Publication Date: 2006-02-15
- Inventor: GRIER, David G.
- Applicant: UNIVERSITY OF CHICAGO
- Applicant Address: 5801 South Ellis Avenue Chicago, IL 60637 US
- Assignee: UNIVERSITY OF CHICAGO
- Current Assignee: UNIVERSITY OF CHICAGO
- Current Assignee Address: 5801 South Ellis Avenue Chicago, IL 60637 US
- Agency: Lawrence, John
- Priority: US471149P 20030516; US498868P 20030829
- International Announcement: WO2004104551 20041202
- Main IPC: H05H3/02
- IPC: H05H3/02
Abstract:
Static arrays of optical traps can be used to sort microscopic objects with exponential sensitivity to size. Such optical fractionation relies on competition between an externally applied force and the moving objects' differing affinities for optical gradient traps. In a reverse fractionation method, objects that are more strongly influenced by the traps tend to become kinetically locked in to the array and are systematically deflected back into an input flow. In a thermal ratcheting method, patterns are spaced to allow particle diffusion, thus providing the opportunity for forward or reverse movement through the patterns. Unlike other sorting techniques, optical fractionation can operate continuously and can be continuously optimized. The exponential sensitivity arises quite generally from the particle size dependence of the potential wells' apparent widths.
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